Release date: 2017-06-14

Experts asked patients who have been successfully cured to show walking, squatting, and standing on one leg of the affected area. This photo is taken by Zhang Yuming

I will go straight for a while, jump on one leg for a while, and do a leg exercise for a while... On the morning of June 6, Xi'an Fourth Military Medical University Xijing Hospital orthopedics showed that Kong Jun (pseudonym) from Gansu was counted A group of media reporters are crowded. He is the first person in the world to benefit from the "general engineering regenerative bone repair large segment bone defect technology".

In September 2014, 35-year-old Gansu patient Kong Jun (pseudonym) was accidentally injured by a stone in a mine in Xinjiang, resulting in an open fracture of the lower extremity humerus, in which a large fracture of the right leg tibia was lost. The local hospital recommended amputation surgery, and then installed prosthetic limbs. Finally, Kong Jun family and he chose conservative external fixation surgery, but Kong Jun has since rushed to the wheelchair for medical consultation.

On the fourth month after the operation, Kong Jun, who was unable to carry the weight on the ground and could only rely on the wheelchair, went to the Xijing Hospital of Xi'an Fourth Medical University. The review revealed that the right leg tibia bone defect was up to 12cm. Fortunately, it was Professor Yu Guoxian's research team that was consulted by Kong Jun. After careful consultation, the hospital decided to use the research team's 20-year research results - tissue engineering regenerative bone technology to relieve his pain.

As one of the earliest teams engaged in tissue engineering and regenerative bone research in China, the research team of the Department of Orthopaedics of the Xijing Hospital of the Fourth Medical University has been focusing on the role and mechanism of tissue engineering, bone marrow cell source, blood vessels and nerves in tissue engineering bone construction for 20 years. Simultaneous construction of neuralization and tissue engineered bone, key technologies before clinical transformation, and research, from small animals (mouse, rat, rabbit), large animals (goats), advanced animals (rhesus) to human bone marrow source The series of MSC culture and phenotypic identification, the development of standard preparation process, and preliminary grasp of the response to this international medical problem. In the world, it is the first to propose a new concept of vascular, nerve and tissue engineering bone synchronization, and successfully built it in large animals and higher animals. It has obtained 20 national 973, 863 and National Natural Science Foundation key topics. The research content was written into the United States. The textbook has won 10 domestic invention patents and 1 international patent. These breakthroughs lay a solid foundation for tissue engineering bone regenerative medicine technology from laboratory research to clinical application.

The expert displays a composite autologous stem cell model at the surgical site of the patient.

On August 3, 2015, the team of Professor Xi Guoxian of the Department of Orthopaedics of Xijing Hospital performed surgery for Kong Jun. After careful preparation in the early stage, the research team detailed the clinical transformation application program of tissue engineering regenerative bone, and officially implemented the international cutting-edge technology after the patient's informed consent and approval by the Xijing Hospital Ethics Committee. Before the operation, the research team took the patient's autologous bone marrow, performed in vitro isolation and culture expansion, obtained enough seed cells - autologous bone marrow stromal cells, and applied the clinically approved tricalcium phosphate material according to the CT data of the patient's bone defect. The biomaterial scaffold with the shape and size of the right tibia defect in the patient. The obtained autologous cells are then inoculated onto the tissue engineering bone biomaterial scaffold and cultured in a bioreactor independently developed by the team for two weeks, so that the autologous cells and the porous bone scaffold are fully compounded and grown, and cultured in vitro to form a patient. Individualized tissue engineered regenerative bone complexes. Three months after the operation, Kong Jun can walk down the ground, 6 months to abandon the gradual walking down the weight, 12 months to remove the external fixation stent has been used for 2 years, walking and lower extremity joint activities are not affected, return to normal life And labor ability. On June 13, 2017, 22 months after the operation, the patient came to the Xijing Hospital of the Fourth Medical University. The bone defect was completely repaired after medical examination. The joint activities and actions were like ordinary people. Checked by technology: This case is the first case of weight-bearing bone defect in the world that has been repaired by tissue engineering method and has a length of more than 10 cm.

Experts announced that this is the first world-wide tissue engineering repair of large bone defect technology in Xijing Hospital.

Qi Guoxian told the Science and Technology Daily reporter that the success of this operation marks the development of the tissue engineering regenerative bone technology from the laboratory to the clinical application, which is a major breakthrough in translational medicine in China. He joked that the human body is a natural incubator, taking the patient's own cells and merging them with the absorbable biomaterials, implanting them in the patient's body. The two are like two people falling in love, not fighting, absorbing each other, and growing up, also To achieve integration, this is not a cold material but a living active bone.

Yan Guoxian revealed that in the next step, the Department of Orthopaedics of Xijing Hospital is organizing a number of hospitals in China to set up a multi-center clinical transformation team, improve the clinical transformation application program of tissue engineering regenerative bone, formulate a consensus on the clinical application of tissue engineering regenerative bone, and promote the application of the latest international Cutting-edge technology, in order to apply to more cases, to save more disabled patients.

Source: Science and Technology Daily Xi'an News Network

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