Research overwork? too much stress? Beware of "Ya Yu"

Research overwork? too much stress? Beware of "Ya Yu"

August 24, 2016 Source: Bio Valley

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What is the "Ya Yu" disease?

Yarrow syndrome, also known as chronic fatigue syndrome/myalgic encephalomyelitis (CFS/ME), according to the FDA's March 2014 issue of Chronic Fatigue Syndrome/Myalgesic Encephalomyelitis (CFS) /ME) Draft Guide", CFS as a complex disease that is debilitating, its exact cause is unknown, clinically manifested in a variety of symptoms, such as severe fatigue and fatigue, muscle and joint pain, memory, sleep dysfunction, etc. Multiple body systems.

The disease was first proposed by the United States, and in 1994, the US Centers for Disease Control and Prevention CDC officially defined "Chronic Fatigue Syndrome" (CFS), and many countries prefer to use "myalgic encephalomyelitis" (ME). .

In 2003, the Canadian Clinical Case Definition Center proposed that in addition to the need for patients with unexplained fatigue for more than 6 months, the ME standard also requires signs of wilting after fatigue. According to the latest report of the Institute of Medicine (IOM) in 2015, chronic fatigue syndrome was renamed "Systemic Overwork Incompetent Disease" (SEID).

Considering that the name of chronic fatigue syndrome is too many, for the sake of simplicity and memorization, the following Bio Valley Xiaobian temporarily calls it CFS/ME.

"Ya Wei" is difficult to diagnose

According to the US CDC, one out of every 4 million Americans has CFS/ME, but the diagnosis is difficult and there is no effective drug for this condition. Therefore, CFS/ME has become a clinical requirement. Unmet public health issues.

The study found that CFS/ME patients did not relieve fatigue after sleep or rest, their pressure-effect nervous system and the integrity of the physiological system were missing, and the patient's stimulation of the external or external environment of the body remained very sensitive. Even in a sleep state, this pressure-sensitive system remains highly alert.

Because the clinical manifestations of CFS/ME patients can not find the exact lesions or causes, patients are often labeled as "the person who is ill to evade responsibility", many patients have fatigue and discomfort after the event, and in severe cases Losing self-care ability, affecting the work, study and daily life of patients. But in fact, in the eyes of scientists and clinicians, this is not what people call "lazy cancer patients". This disease is as real as diabetes, cirrhosis and other diseases.

However, the symptoms of CFS/ME are not typical, and there are many similarities with other diseases. Clinicians often misdiagnose them as neurasthenia, menopausal syndrome, endocrine disorders, neurosis, etc., delaying treatment.

"Ya Yu" cause is difficult to find

In 2009, an article in the journal Science published "Science: Retroviruses Associated with Chronic Fatigue", Vincent Lombardi and his colleagues found 2/3 of the blood samples of 101 patients with CFS ( The 68 patients were infected with human retrovirus XMRV, which has similarities to a mouse blizzard virus. At the same time, only 8 of them found XMRV in blood samples from 218 healthy people. Researchers say XMRV is infectious and can trigger an immune response that is present in some human prostate tumors, so it may be present in a significant proportion of the population.

But only in January of the following year, researchers from institutions such as Imperial College of Science and Technology reported in the Science Public Library·Comprehensive that they tested tissue samples from 186 patients with chronic fatigue syndrome, but found no virus. Any trace of XMRV.

On May 31, 2011, Science published an article stating that the association between XMRV virus and chronic fatigue syndrome "has serious problems." The publication of two studies in the journal also showed that the researchers' conclusions two years ago were entirely laboratory theories, and it was almost impossible to demonstrate that the retrovirus infected with XMRV is the real cause of chronic fatigue syndrome.

At present, the cause of chronic fatigue syndrome/myalgic encephalomyelitis (CFS/ME) has not been confirmed.

How to refuse "Ya Wei"

CFS/ME is a self-limiting disease. Many people can recover on their own immunity within two weeks without any treatment. For example, see the student party that drives the night train before the exam. The exam is dark and sleeps for one day, and the next day, another day. I can live alive and thrive.

Given that there is no cure for the disease, the best advice doctors can provide for CFS/ME patients is to rest as much as possible and reduce stress.

1. Respect the biological clock

Many researchers believe that there are many things in the daytime, the lab is noisy, and they can't concentrate on the experiment. Therefore, they are more inclined to experiment quietly in the laboratory at night, and some even drive night cars for several nights. For thousands of years, the body's biological clock has been the law of keeping the "sunrise, sunset and interest", forcibly reversing for a long time, and also interferes with the normal self-repairing activities of cells in the body.

2, in case of difficulties

When scientific research experiments encounter difficulties, and there is no way to do anything, don't put too much pressure on yourself. You should not confine yourself to thinking and thinking, to relax, adjust your mentality, and seek teachers and lab teachers to discuss solutions. Maybe you can get unexpected inspiration.

3, not afraid of "exit"

When you are overwhelmed by scientific research tasks and are difficult to break free, you are not afraid to "exit". Perhaps your pressure tutor is not clear. Perhaps these tasks are beyond your scope of responsibility. Perhaps your high self-expectation is beyond the scope. ························································································

4, balance multiple goals

Degrees, projects, job search, promotion, no matter which one, are not sloppy goals, but these require energy and time to pay. If you ask yourself that you are not competent at the same time, it is better to calm down and balance these goals. Prioritize, don't set too many goals for yourself, too much pressure.

5, overworked irreversible

Health is your own, and your inner peace and calm are your own. You are conscientious in scientific research. You may not be comfortable on the road of publishing papers and appraisal titles. An impulsive, working overtime, day and night may cause overwork. And these injuries to the body are irreversible, and money and fame are equally irreversible, but you are worried about your family and friends.

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