Gene sequencing (detection) technology refers to a technique for analyzing and detecting DNA by blood, body fluids, cells, and the like. From the evolution of technology, international gene sequencing technology has been mainly through three generations: the first generation sequencing technology is based on the sequencing principle of the dideoxy termination method invented by Sanger and Coulson in 1975, combined with fluorescent labeling and capillary array electrophoresis technology to achieve automatic Sequencing. A common feature of the second generation of sequencing technology is the high throughput achieved at the expense of read length. The third-generation sequencing technology, ie single-molecule DNA sequencing, distinguishes base signal differences by means of modern optics, polymers, nanotechnology, etc., and directly reads sequence information. The main feature is that no biological or chemical reagents are needed, further reducing the cost of sequencing. .

At present, more than 1,000 diseases can be diagnosed by gene sequencing (detection) technology. Genetic testing technology not only predicts and prevents interventions before the disease occurs, but also produces good economic and social benefits. Vigorously developing and promoting genetic testing technology is of great significance for accelerating the development of China's bio-industry and health industry and improving people's quality of life in an all-round way.

The state attaches great importance to the genetic industry. At the end of December 2014, the National Health and Family Planning Commission issued the Notice on Launching the Pilot Work of Clinical Application of High-throughput Gene Sequencing Technology. In June 2015, the National Development and Reform Commission incorporated genetic sequencing (detection) technology into the country's emerging industry major engineering package, supporting 30 genetic testing technology application demonstration centers within three years. In 2016, precision medicine was included in the national “13th Five-Year Plan”; as the vanguard of precision medicine – genomics was also included in the “13th Five-Year Plan” list of projects, “to accelerate the large-scale application of biotechnology such as genomics”.

The National Development and Reform Commission issued the “Response on the Construction of the First Batch of Gene Detection Technology Application Demonstration Centers” (Development and Reform Office High Technology [2016] No. 534), and 27 gene sequencing (testing) technology application demonstration centers were officially Reply. At present, the national genetic sequencing (detection) technology application demonstration centers of various provinces and cities have started construction or start. In addition, after nearly five years of construction, China's first national gene bank in Dapeng New District of Shenzhen has started trial operation.

The strong support of national policies and the huge development space of the industry will enable the gene sequencing industry to usher in the golden period of development. In order to understand the status of China's gene sequencing technology and industry, this paper starts with China's gene sequencing patents, researches and analyzes the development trend of gene sequencing technology industry, important research and development institutions, major innovative talents, key development areas and other related information, in order to sequence genetic detection in China. ) Provide a reference for the development of the technology industry.

Chinese Gene Sequencing Patent Analysis

Related patents for gene sequencing technology appeared in the 1980s. China's gene sequencing patent technology developed late. Before 2000, China's gene sequencing patent technology was basically in the gestation period (Figure 1, Figure 2). With the rise of international second-generation technology, China's gene sequencing patent technology was also realized in 2001. A certain breakthrough, after the development of genetic sequencing technology encountered obstacles, China's related patent applications / public display showed a slight decline, consistently continued until 2007. After 2008, with the emergence of the international third-generation gene sequencing technology, China's gene sequencing patent technology has shown a rapid growth trend, and the technology life cycle has entered a growth period.

The top 20 applicants for China's gene sequencing patent ownership rankings are shown in Figure 3. Huada Gene is far ahead of the 827 gene sequencing patents. Yishan Biotechnology Co., Ltd. and Zhejiang University ranked the second and third respectively with 206 and 189 gene sequencing patents. More than 60 genetic sequencing patent applicants also There are Shanghai Jiaotong University (152), Beijing Zhongke Zixin Technology Co., Ltd. (96), Southeast University (81), and Jianghan University (66). The applicant ranked No. 10 (tied) is an individual--Shenzhen Huayinkang Gene Technology Co., Ltd. founder and chief technology officer Sheng Siwei (49 pieces).

The application trend of the top ten applicants for Chinese gene sequencing patents is shown in Figure 4. Although China has patented gene sequencing since 1989, the first ten patent applicants to start genetic sequencing patent applications were also in 2000, indicating that Chinese related gene sequencing applicants started late but developed rapidly. grow. Representative of them are Huada Gene, Zhejiang University, and Beijing Zhongke Zixin Technology Co., Ltd.

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