Release date: 2015-03-03

Is there a day when the organs of the living body can achieve 3D printing and replace the "original" organs? The research results of the research work of the research team of the Department of Chemistry of Tsinghua University, Liu Dongsheng, "DNA Hydrogel" has taken a step forward from this material.

Recently, the DNA hydrogel material of Liu Dongsheng's research group and Will Shu (Wu Shu) of the University of Watt, UK, has been successfully applied to 3D printing of living cells. The paper is in Applied Chemistry of Germany (Angew. Chem., Int. Ed.). DOI: 10.1002/anie.201411383) published with a "Press Release" key report. The result was reported in the February 26 issue of Nature's research highlights, which Nature evaluated as "a very promising material for printing three-dimensional tissues and artificial organs."

3D printed DNA hydrogel particles of different sizes (with blue dye added for added visibility), with multiple prints, the maximum size can be up to centimeter and can be self-supporting (upper right panel).

Nature also commented: "This gel can achieve centimeter-scale structure construction through multi-layer printing", "has enough strength to maintain its shape, does not collapse or swell, but can be (specific) endonuclease Rapid dissociation", "co-printed living cells can remain active."

Due to its high water content and similar to the characteristics of extracellular matrix, hydrogel is the preferred substrate for three-dimensional tissue printing and artificial organ preparation, and has become a research hotspot in the fields of chemistry, materials and life medicine. However, until the development of DNA hydrogel, there was no hydrogel material that could meet the harsh conditions of cell compatibility, mechanical strength, permeability, rapid prototyping, etc. required for three-dimensional printing of living cells.

For the breakthrough point of this research, Professor Liu Dongsheng explained: "The significance of this achievement is that we have prepared a new class of hydrogel materials that can meet the needs of multiple living cell 3D printing at the same time: fast, can Achieve second-order molding; mild conditions, the process is completely completed under physiological conditions, does not involve chemical reactions and external stimuli that can cause damage to cells; strength, permeability is good, the final size of printed products can reach the scale above the centimeter level It does not deform and soften, but also ensures the transport of nutrients required for cell growth. This material also has very good thixotropic and self-repairing properties. It can continuously change its structure while maintaining cell growth, and can guarantee the supply of cells. In the case of sufficient support, the expansion is not limited; more importantly, the gel material can be quickly decomposed and left as needed, creating conditions for the future transplantation of 3D printed organs."

Source: Tsinghua News Network

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