Release date: 2017-07-21

Recently, the Cancer Research UK and the British biotechnology company Owlstone Medical announced a clinical trial to find potential biomarkers from the respiratory of cancer patients. The purpose of this trial is to test cancer-related volatile organic compounds in the breath to help doctors make rapid, non-invasive diagnoses.

Cancer is one of the number one health killers facing humanity today. Although the field of cancer treatment has made great progress in recent years, the overall survival rate is still unsatisfactory for many cancers. A consensus in the industry is that the sooner a cancer is discovered, the more effective its treatment. Therefore, improving the early diagnosis rate of cancer is one of the key means to increase the survival rate of patients. Sensitivity and accuracy are indispensable for early cancer screening, but the convenience and non-invasiveness of testing is also important.

Owlstone Medical has developed a completely non-invasive respirometer, the ReCIVA Breath Sampler, which collects all volatile organic compounds from the patient's breath samples and sends them to the company's first respiratory biopsy laboratory in the world. For analysis, the laboratory analyzes organic compounds in breath samples with high sensitivity and selectivity and looks for links to cancer.

Principle of ReCIVA Respiratory Detector (Source: pharmaphorum)

The company's initial goal was lung cancer and colorectal cancer, and a ongoing clinical trial in patients with suspected lung cancer enrolled 3,000 patients. This figure is in the midst of the company's sensitivity and specificity to the trial data. After the analysis. At the same time, another trial in patients with colorectal cancer plans to recruit 1,400 patients.

The PAN Cancer trial, conducted by Owlstone Medical in collaboration with the British Cancer Institute, extends the focus to a variety of cancers including bladder cancer, brain cancer, breast cancer, head and neck cancer, kidney cancer, esophageal cancer, pancreatic cancer and prostate cancer. If the trial succeeds in finding biomarkers in the breath associated with each type of cancer, the company will rapidly expand its clinical R&D pipeline to include these new cancer types.

Rebecca Fitzgerald, a principal investigator in the clinical trial and a professor at the University of Cambridge, said: "We are in desperate need of new tools for early diagnosis of cancer. We are very pleased to work with Owlstone Medical to test its respiratory biopsy platform. The PAN Cancer trial is ours. Part of the early detection program, the flagship program of the Cambridge Cancer Centre of the UK Cancer Institute, aims to find better ways to diagnose cancer early and bring more effective therapies to patients."

Olwstone CEO Bill Boyle demonstrates a breath detector (Source: businessweekly)

Mr. Bill Boyle, co-founder and CEO of Owlstone Medical, said: "The positive results of the PAN Cancer trial may change the entire cancer treatment arena, and respiratory biopsy for early diagnosis of cancer is expected to greatly improve the survival rate of a range of cancers. Our breathing The biopsy platform has been evaluated in large clinical trials of lung and colorectal cancer, and it is exciting to test whether it can be used for other cancers. The success of this research will affect the lives of millions of people and support us to save. 100,000 lives and a goal of saving $1.5 billion in medical expenses."

Owlstone Medical has received more than $23.5 million in financing since its separation from parent company Owlstone Inc. in 2016. We hope that the company's clinical trials will proceed smoothly, making respiratory cancer testing a reality and helping more cancer patients.

Reference material

[1] Owlstone Medical and Cancer Research UK (CRUK) Initiate Pan Cancer Clinical Trial to Evaluate Breath Biopsy for Early Detection of Disease

[2] Owlstone, CRUK start hunt for breath biomarkers of cancer

Source: WuXi PharmaTech (Wei Signal WuXiAppTecChina)

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