Pharmacological effects

1, anti-tumor: Indigo ingredients Indirubin 200mg/kg intraperitoneal or subcutaneous injection, continuous 7 days, inhibition of rat tumor W256 solid tumor, 100mg/kg intraperitoneal injection of mouse sarcoma -180 (S180) inhibition . Indirubin 50mg/kg gavage for 10 consecutive days, inhibited Lewis lung cancer in mice. Indirubin treatment of chronic myeloid leukemia, bone marrow leukocytes abruptly reduced, electron microscopic observation of a large number of degenerating necrotic cells, and both are immature granulocytes, are carried out in a manner of swelling, dissolved necrosis, cytoplasm, nuclei are clearly destroyed . Indirubin 200mg/kg intraperitoneal injection for 3-5 consecutive days, the inhibition rate of (3H-TdR) incorporation into rat W256 tumor tissue deoxyribonate (DNA) was 46%, but did not inhibit 3H-uridine ( 3H-UR) Incorporation of ribonucleic acid (RNA) and 3H-phenylalanine in tumor tissue into proteins in tumor tissue. In vitro test, indirubin at concentrations below 3×10(-6) mol/L inhibits 3H-TdR incorporation in rat W256, mouse Ehrlich ascites carcinoma (EAC) and mouse hepatoma (HepA) Into the cancer cells, but the inhibition of regenerative hepatocytes is minimal, no effect on nucleic acid and protein synthesis of mouse lymphocytic leukemia (L1210) cells. Indirubin 4 μg/ml inhibited the incorporation of TdR into human chronic myelogenous leukemia (CML) cells, and inhibited the incorporation of acute TdR particles more rapidly, indicating that indirubin is more effective for proliferating cells with more active DNA synthesis. Large inhibitory and killing effects, but no inhibition of TdR incorporation into naive lymphocytes.

2, the role of leukemia cells: pharmacological studies have initially shown that indirubin has a role in the destruction of leukemia cells. From the ultrastructural morphology, under the effect of Indirubin, degenerated and necrotic cells are mostly swollen and soluble necrotic. It was found that indirubin can enhance the phagocytic activity of the mononuclear macrophage system in animals. The mononuclear macrophage system plays a role in the body's immune response, so the anti-cancer effect of indirubin may be related to improving the body's immunity.

3, antibacterial effect: tryptophan by anti-fungal test, anti-dermatophyte fungi active ingredient, on the microsporum-like wool, broken hair, gypsum-like microsporum, purple mushroom, gypology-like bacteria, red Fusarium oxysporum, Epidermophyton floccosum, etc. all had a strong inhibitory effect, and the minimum inhibitory concentration was 5 μg/ml.

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