SCIEX, a life sciences analysis technology company, announced on March 29 that it has added new members to its growing family of drug discovery and development solutions. Conventional biotransformation solutions and advanced biotransformation solutions use SCIEX's new MetabolitePilot 2.0 software.

These new solutions automate the study of small molecule metabolism and biologic catabolism and speed up research. Both solutions feature automated structural interpretation, advanced processing options, and antibody-coupled drug (ADC) analysis templates that provide intuitive metabolic data processing to increase the efficiency and cost savings of routine and comprehensive metabolite identification studies.

Biotransformation research is an essential component of small molecule and macromolecular drug development. Whether researchers are in desperate need to find soft spots in drug discovery and identify metabolites, or if they want to be confident in determining all detectable metabolites or peptide breakdown products in drug development, SCIEX offers an integrated solution that meets the needs of scientists. Program.

SCIEX's conventional biotransformation solution consists of the ExionLC® AD system, the X500 Series QTOF System (Quadrupole Time of Flight) platform and MetabolitePilot 2.0 software. The user interface of the SCIEX operating system is simple and easy to use, helping pharmaceutical researchers simplify the high-throughput metabolite identification and soft-point analysis of small molecules and macromolecules. The solution identifies major metabolites of compounds and reports to chemists and biologists in the simplest possible way to quickly and accurately complete high-throughput screening, thereby reducing project cycles.

SCIEX's advanced biotransformation solution uses the objective and unbiased SWATH® acquisition technology on the SCIEX TripleTOF® 6600 system to perform in-depth, comprehensive metabolic/catabolic studies in a single injection. Today, with MetabolitePilot 2.0 software, pharmaceutical researchers who need to fully identify all metabolites and biotransformation products of molecules are able to automate the processing of metabolite and breakdown product data, enabling highly accurate identification of traditional small molecule metabolites and complex organisms. The structure of the decomposition product of the preparation.

“As of now, there are not many processing software available to customers when conducting biologic catabolism studies. In addition, data processing and interpretation are usually done manually, time-consuming and labor-intensive. These new solutions using MetabolitePilot 2.0 software can Intelligent processing of biologic catabolic data,” said Farzana Azam, senior director of SCIEX Pharmaceuticals/CRO Business. “By combining the SWATH acquisition technology, researchers can perform analysis in a single injection and achieve full coverage of the sample. This gives them the confidence to not miss any important low-level metabolites/decomposition products. Biotransformation solutions offer flexible options for rapid identification of metabolites and decomposition products, as well as deeper metabolism and catabolic studies , can also achieve fast processing."

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