Cardiovascular system effects

Puhuang extract has a significant effect on the increase of coronary blood flow in isolated rabbit hearts. Puhuang water decoction and Pu-Huang-based Compound Xinshu III decoction all can accelerate the blood flow velocity and capillary opening rate of golden hamster entrapped microcirculation arterioles; also have myocardial microcirculation in mice. Improve the role. Puhuang has a protective effect on myocardial damage in rabbits. The left ventricular branch artery is ligated to form an acute myocardial infarction model. After treatment with Puhuang, the scope of myocardial infarction in rabbits can be reduced and the lesions can be reduced, which can also make the model home. The ratio of circulating platelets in rabbits increased, indicating that the anti-platelet aggregation of puhuang may be one of the mechanisms of anti-myocardial ischemia. The extraction of isolated daffodils from the pollen of Changbaixiang can significantly protect the rat myocardial ischemia induced by pituitrin and increase the uptake rate of myocardial 86Rb in mice, which is presumed to be related to the calcium antagonistic effect of daffodil. Large doses of Puhuang have antihyperbaric and hypoxic effects and increase animal tolerance to decompression and hypoxia. Pueraria alcohol extract can prolong the disappearance of electrocardiogram in mice that trap tracheal mice and ligation of common carotid arteries; it can increase isoproterenol-induced oxygen depletion and prolong survival of tail iv air; but There was no prolonged hypoxia death time in mouse tissues caused by NaNO3. It indicates that Puhuang enhances the tolerance of the myocardium and brain to hypoxia or reduces the oxygen consumption of the heart, brain and other tissues, and has a protective effect on the heart and brain hypoxia. The principle may be to prevent the decrease of ATP and ADP content in the myocardium and make the brain Increased activity of Na-K-ATPase and Mg-ATPase on the cortical cell membrane accelerates ATP breakdown, increases central inhibition, improves hypoxia tolerance, and restores or nearly normal levels of hypoxic cardiac and hepatic superoxide dismutase. , Increase brain tissue and arterial oxygen partial pressure, reduce oxygen consumption and lactic acid content.

Puhuang extract has reversible inhibitory effect on isolated frog heart and rabbit heart, and when the concentration is high, the heart is arrested in diastolic state; and it has the effect of lowering blood pressure in rabbits. The inhibitory effect of Puhuang on the heart may be related to quercetin (also a cholinesterase inhibitor) contained in Puhuang. The isoniazid lanthanum in the pollen powder of the Changyi cattail has the activity of increasing the myocardial cAMP level.

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