Release date: 2015-04-21

Recently, scientists from Switzerland said that cancer DNA circulating in the blood of patients with lung cancer can provide doctors with important mutation information to help doctors optimize cancer therapy in cases where patient tumor tissue is not easily targeted; Research has provided new ideas for the effective use of cancer therapies to target mutations in specific cancers.

It is not always possible to detect mutations in the tumor itself, but many studies have shown that circulating tumor DNA in the blood of a patient's body may provide some important indications. In this study, the researchers aimed to compare the differences between standard methods for detecting tumors and using blood to detect EGFR mutations. Reck says that even if a lung tumor cannot be detected by bronchoscopy or CT-guided biopsy, is there a method available to help detect mutations in EGFR and can provide ideas for developing super therapy? And whether blood tests can be used Do you get the same results as the Gold Standards Act?

In this study, the researchers tested 1,162 matched tissue and blood samples, and the results showed that blood tests and 89% of the results obtained by standard tissue detection methods, and blood tests can identify half of EGFR mutations. Patients, and the sensitivity of tissue testing is only 46%. Rafael Rosell said that for cancer patients, cell-free blood DNA testing is an effective tool to help detect genetic changes in tumor tissue, and relevant findings can help scientists confirm that in almost half of lung cancer patients or The EGFR mutations carried by them can be directly detected in plasma.

This study may help improve current technology for EGFR mutation sensitivity testing in lung cancer patients; this study will also be used for more in-depth studies to extend the routine use of detection mutations, such as EGFR mutations as part of the treatment of cancer patients .

Source: Bio Valley

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