A research team led by Leonid Kruglyak of UCLA has developed a new technology that uses the genetic editing system CRISPR to quickly identify genetic variants. The findings may significantly advance research efforts to map genes and determine their function. Related papers were published in the May 5th issue of Science.

Finding differences in DNA sequences that are the basis of trait variation is a central goal of modern genetics research. The main tools currently associated with genotypes and phenotypes are linkage and association studies. Although linkage and association studies have mapped tens of thousands of genomic regions that contribute to phenotypic variation, narrowing these regions to potential pathogenic genes and mutations can be challenging.

Traditionally, it has been found that genetic variation has been limited to research at low-resolution naturally occurring meiotic recombination rates. During meiotic recombination, cells undergo two divisions to produce germ cells, and genetic material is “reshuffled”. Usually, because the meiotic recombination rate is too low to analyze the mapping region of a single gene, let alone the specific variation within the gene.

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