Human pig "fit": human stem cells combined with porcine DNA

Original title: Human stem cells bind to porcine DNA, and human pig "fit" embryos can survive for 28 days.

[ China Pharmaceutical Network Technology News ] With the development of medicine, more and more incredible therapies have entered people's field of vision. According to the British BBC and the Daily Mail, more than 1,000 people in the UK lose their lives each year due to the lack of suitable donor organs. If the idea of ​​cultivating human organs in animals can be realized, there will be countless patients who can benefit from them. Simply relying on the lack of personal donation channels.


In January 2016, the UK issued a license for its domestic universities, allowing research labs in the country to conduct research on relevant content in the future, paving the way for the development of human organ cultivation projects in the UK and hopes to take the opportunity to maintain the UK. A leading position in the world of genetic engineering.

Recently, British scientists announced the successful completion of human stem cell and porcine DNA binding experiments. The growing embryos were placed in experimental pigs for up to 28 days, but no shaped human-functioning organs were born.

"Human - pig chimeric embryo" of the production process shown in FIG. <br> <br>: "Man - Pig chimeric embryo" production process includes five steps:

1) extracting DNA related to pancreas synthesis from pig embryos;

2) injecting human stem cells into the embryonic tissue;

3) Transplanting "human-porcine chimeric embryos" into sows;

4) The normal growth of the fetus in the sow, only the human stem cells enter the pancreatic tissue;

5) After the sow is pregnant, when the pancreatic tissue and organs grow to the same size as the human pancreas, organ transplantation is performed.



Injecting human stem cells into the pig's embryo, the cells are clearly visible at the right resolution

Therefore, in this technique, the embryos in the sows are still normal piglets, but there are human stem cells in the body.

The "challenge" of cultivating human organs in animals

For a long time, there are two major difficulties in cultivating human organs in animals. One is that the human body itself will react to foreign organs; the other is that organ transplantation may cause animal bacteria to transfer to the human body.

But now, scientists have solved these two problems, they successfully cracked the pancreatic cell DNA of pigs, and determined the future changes of the embryo by implanting accurate gene sequences into human blank stem cells. The mixed cells will be placed in the body of the adult sow and eventually grow into human pancreatic organs.

Why choose pigs as embryonic cell carriers?

According to Walter Low, a professor at the University of Minnesota, the pig is the most ideal natural incubator for all animals. The human organs cultivated in pigs will be younger and healthier.

The ethical controversy "human-porcine chimeric embryos" has also attracted a lot of criticism from scientists. Opponents believe that such human pig cell binding experiments are offensive to human dignity; and whether cell mixing will lead to some experimental animals possessing Human thinking and IQ.

In response to this question, Dr. Pablo Ross, the leader of the experiment, said that the possibility of embryo development into the brain is minimal, and they will avoid these problems as much as possible in the later experiments.

At the same time, Professor WalterLow also said that once organ culture is out of control, they will immediately stop such experiments.

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