Pharmacological effects

1, hypoglycemic effect: rabbits fed 25g/kg guava juice, the normal rabbit blood glucose value decreased by 19%, while diabetic rabbits decreased by 25%, the efficacy of drugs in the 4 hours after taking the highest, 24 hours The original blood glucose level is restored.

2, the role of hemostasis: Gallic acid extracted from the guava to the family to avoid intravenous injection of 20mg/kg, can shorten the average clotting time by 51%.

3. Anti-fertility effects: The guava root decoction has obvious effects on anti-fertility, anti-implantation, anti-pregnancy and mid-term induction of labor; the route of administration is best for intraperitoneal injection, followed by subcutaneous administration, followed by oral administration. It is almost ineffective; it has the effect of enhancing contraction in vitro and in vivo in the uterus, especially in the uterus of pregnancy; when combined with prostaglandin E2, it has a significant synergistic effect on early pregnancy and excitability in isolated uterus; Its mechanism of action may be to damage the placental trophoblast cells, causing degeneration, necrosis, and may also interfere with the secretion of progesterone. The anti-fertility active component of guava root may be tannins, especially guava ellagic acid glucose.

4, toxicity

The subcutaneous injection site of guava decoction mice showed crusting and tissue necrosis. The intraperitoneal injection had a stimulatory effect. The larger dose had liver damage, and the guava decoction mice had an intraperitoneal lethal dose of 2.84 g (crude drug)/ Kg.

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