Human placenta map based on 70,000 cell scientists
Human placenta map based on 70,000 cell scientists November 15, 2018 Source: Science and Technology Daily Author: Zhang Meng Ran British scientists published a paper in the journal Nature on the 14th that they mapped the map based on about 70,000 cells in the early human placenta. This achievement is expected to bring new insights into cell tissue and cellular communication in early human pregnancy, and it also explores mechanisms for maintaining physiological stability that are critical to pregnancy success. In the early stages of human pregnancy, the fetal placenta is implanted into the endometrium (decidua), and placental trophoblast cells are mixed with the mother cells. This relationship is critical for pregnancy success, but cell interactions within the decidua of early pregnancy are still unclear. International research projects such as Human Cell Atlas are trying to identify all cell types involved in development, health and disease. Sarah Tachman, a scientist at the Wellcome Sanger Institute in the UK, and colleagues are also working on this. They describe the transcriptome of about 70,000 cells in the placenta of human early pregnancy (6 weeks to 14 weeks). Gene expression of the RNA molecule set), and matching maternal and decidual cells. The team studied the molecular interaction between fetal cells and maternal cells at the placenta-decidual interface and used the data to develop a new statistical tool (CellPhone) to predict potential special intercellular interactions. The research team discovered the specialized functions of individual cell subpopulations and identified regulatory interactions that may help minimize the harmful maternal immune response. In addition, they identified three major subpopulations of decidual natural killer cells (dNK). They believe that during the first trimester, the interaction between dNK1 subpopulation cells and specific placental cells may allow dNK1 cells to respond more effectively to placental implantation during re-pregnancy. In the accompanying news article, the National Institutes of Health scientists believe that the discovery provides important information for understanding early human pregnancy, and clinically will be important to improve the diagnosis and treatment of pregnancy-related diseases. Anesthesia Medical Co., Ltd. , https://www.honestymed.com