Release date: 2017-11-10

On November 8th, the smell may be the key to a more accurate, cheaper and non-invasive diagnostic test in the future, and malaria, cancer and Parkinson's disease may be diagnosed by this method. Israeli scientists are conducting a breath test that allegedly detected 17 diseases. At the same time, a US team is testing equipment for identifying malaria respiratory characteristics in Malawi, Africa. Both of these techniques rely on the chemical composition of the healthy population to exhale and the patient group exhale.

Although these two technologies are not yet ready for clinical use, scientists at each team hope that odor testing technology will quickly allow patients to experience painless and cheaper diagnostic procedures. We have always known that diseases have a unique smell. And the service dog can sniff out through training and remind people of epilepsy and even cancer.

Scientists are now using technology to "sniff" diseases that human noses cannot find. The research team at the Technion of Israel has created Na-Nose, a device that detects up to 17 diseases. The research team announced that the new technology can recognize many different kinds of diseases.

A person's breathing is made up of many chemical components, and each person is different. This difference may be due to gender, age, ethnicity, and many other biological factors. Na-Nose's researchers claim that the range of diseases it can detect includes certain cancers, multiple sclerosis and Parkinson's disease. At present, the accuracy of this system to detect diseases has reached 86%.

Dr. Audrey Odom John of the University of Washington is developing similar technologies to detect malaria. She claims that her breathing analysis method can reach an accuracy of about 83%. In contrast, the accuracy of traditional methods of diagnosing disease by blood testing is close to 90% to 95%.

Dr. Odom John has been testing the accuracy of this new technology on children in Malawi, Africa. Malaria is more prevalent in tropical regions such as Malawi, with the most severe cases among children. She and her team identified six respiratory odor compounds from sick children. Therefore, about 83% of children who have all six compounds in their breath are likely to have been ill.

At present, the diagnostic test of this method is only performed on children, so it is not clear whether it is equally effective in adults. But Dr. Odom John hopes to reproduce this diagnosis in adults, and hopes to develop a more sensitive spectrometer to analyze the gas composition of the patient's breathing.

Respiratory testing is particularly important in the diagnosis of malaria because it has some resistance to current blood test diagnoses. Dr. Odom John said: "In some areas, rapid blood tests do not fully diagnose patients because they lack a specific protein. Some diseases have stopped the production of this protein, which is a key component in blood test diagnosis. ."

Respiratory test diagnosis may eventually become cheaper, more sustainable, and not invasive, which is a very important factor for children. Traditional blood tests that are currently slower require only a few cents (US dollars), but require trained people to draw blood, as well as microscopes and other trained people to analyze the blood. All of this adds cost to blood testing. The method of rapid blood testing requires only between 50 and 1 US dollar, but for some areas the price of this diagnostic method is too high.

Dr. Odom John's team is working with bioengineers to develop a device similar to a breath analyzer, and she hopes to use a sustainable and cheaper cardboard mouthpiece. Like Na-Nose's research team, Dr. Odom John hopes that respiratory diagnostics will eventually be used to test a variety of diseases, and ultimately even give us more information than blood tests.

Dr. Odom John said: “Everyone hates throat swab sampling, but it is difficult to diagnose whether pneumonia is viral by blood test.” She hopes that respiratory testing technology will one day free us from antibiotics and anti-malarial drugs, so we will The ability to use our best medicines in patients who really need treatment.

Source: NetEase Technology Report

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