Following the investigation of the cataract "Shenzhen" Shapu Aisi eye drops was exposed, another "God medicine" Pidotimod was founder of "Question Pharmacist", pharmacist outpatient director of Beijing Hejia Hospital, and Pharmacy of Peking Union Medical College Master's Qilian Mei's skin.

According to her, this imported drug is still in the stage of white mice in foreign medical clinical trials. The effect is not clear, but in China it has become an expensive "magic drug", which is abused in major hospitals, and sales are expected to reach 40. 100 million yuan. Qi Lianmei suggested that relevant departments re-evaluate the clinical efficacy of Pidotimod.

Pediatric "God Medicine" is almost "is sick"

Qilian Meifa's article reflects that on the online consultation platform of the WeChat public account, the consultation on Pidotimod oral solution can be seen almost every day.

After a thorough review, she discovered that the drug was the darling of pediatrics, otolaryngology and dermatologists. From the three departments, the children who were sick were almost all of them. The figure, the line is generally: prevent a cold from coming to a box, a fever, cough, a box, rhinitis tonsillitis, a box, eczema, urticaria, a box...

The price per box ranges from tens to hundreds of dollars, and it is a month's worth of one meal. It is a three-month course of treatment. It is no wonder that doctors will admire it!

According to the data retrieved by the pharmacist online, Pidotimod sold very well in China. In 2016, Pidoti’s sales in domestic grade hospitals reached 3.5 billion, and sales in retail pharmacies were 427 million, plus In other non-grade hospital sales, "I guess the total will reach 4 billion! And most of them are paid for by children," she said in the article.

The reporter found in online pharmacies that Pidotimod is roughly divided into four dosage forms: capsules, granules, dispersible tablets and oral liquid. Among them, granules, capsules and dispersible tablets are domestically produced, the price is 30-40 yuan per box, and the oral liquid is imported from Italy. The price is expensive, the original price of single box is 194 yuan, and the promotional price is 140 yuan.

In the usage and dosage of the oral liquid, Baidu Encyclopedia can be found on the child's onset, twice a day for a total of two weeks or as directed by a doctor. If it is used to prevent disease, once a day, at least 60 days or as directed by your doctor.

Baidu Encyclopedia shows that the drug is an immunostimulating regulator, suitable for patients with low immune function; repeated infection of upper and lower respiratory tract (pharyngitis, bronchitis, bronchitis, etc.); repeated infection of otolaryngology (rhinitis, tonsillitis, Sinusitis, otitis media); urinary tract infection; gynecological infection; can be used to prevent acute infection, shorten the course of disease, reduce the severity of the disease, can be used as an auxiliary medication in the acute infection period.

"God medicine" has four major problems such as unclear clinical efficacy

The official website of the National Food and Drug Administration can be found. The Pidotimod oral solution is imported and produced in Italy. The date of issuance is December 2, 2015, and the validity period is December 2, 2020.

However, Qi Lianmei investigated the major medical websites abroad and found that this imported drug from Italy showed in clinical medical research that the clinical efficacy and safety were not clear. According to Qi Lianmei, there are four major problems with this drug.

Question 1: Researchers are mainly concentrated in China and a few European countries such as Italy and Russia. The two newly published articles in the forefront are the articles of Chinese doctors. Unfortunately, they still stay in the pre-clinical animal research stage. They are not chickens or mice, and have no practical guiding significance for the clinic.

Question 2: In 2015, there was a study in foreign countries to prevent acute respiratory diseases in 57 healthy children who had just entered kindergarten. However, randomized, double-blind, placebo-controlled clinical trials showed that Pidotimod did not show statistically significant effects in preventing acute respiratory infections compared with placebo.

Question 3: What makes Qi Lianmei very surprised is that in the foreign authority-based evidence-based medicine library Cochrane, there is no research on the safety of Pidomemod for children. The domestic research results are almost It's all effective! These results indicate that Pidotimod has good preventive or therapeutic effects on repeated respiratory infections, asthma, urinary tract infections, gynecological infections, hepatitis C, and even non-infectious diseases such as vitiligo, tumors, and allergic purpura. It has become a panacea.

Question 4: The immune system of preschool children is still growing and should not be easily used as a hat with a low immunity. In addition to vaccines that can prevent diseases and improve children's immunity, there are no drugs in mainstream countries in Europe and the United States to improve children's immunity.

"God medicine" efficacy should be initiated and re-evaluated

Qi Lianmei believes that Pidomemod's sales in China are closely related to the pediatrician's preference for this drug. She analyzed that the reason why doctors like to open is mainly based on the following three factors:

The first is income generation. From the outside world, the motivation of doctors to prescribe medicines will be reduced after the hospital implements the zero rate of drugs. However, Qi Lianmei believes that the zero mark rate only reduces the hospital's bonus, and does not cut off the rebate for the doctor.

The second is to prescribe the medicine according to the instructions. In Qi Lianmei's view, some doctors don't pay much attention to the actual curative effect. Some doctors never check the original literature. How do you write the instructions on how to write the instructions? How does his teacher teach him how to believe, maybe his own family and friends, he is also like this. Open, eat like this.

Finally, there are factors that doctors need to comfort or cope with the parents of the child.

Qi Lianmei believes that since this drug has been listed in China for many years and has been used by so many children, she suggested that the State Food and Drug Administration, the competent department of the industry, initiate a re-evaluation of the drug, such as a large-scale retrospective study with a scientifically rigorous design. To evaluate the true efficacy and safety of this drug.

It is reported that in March 2016, when the drug was applied for listing in Pakistan, the country's regulatory authorities heard the opinions of the expert group, namely:

Although this drug has been listed in China, Korea, Russia and other countries for many years, it has not been included in any standard pharmacology textbook, nor has it been approved by the EU drug regulatory authorities and the US drug regulatory authorities. It is effective. Sexuality and safety still require further evaluation and are not recommended for marketing until reliable research evidence emerges. (China Youth Daily)

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