Utilizing tumor immune cells is expected to develop new cancer therapies
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January 06 12:08:47, 2024
Medical Network November 14th Recently, researchers from the University of Edinburgh have developed a new technology to reveal the differences between immune cells in tumors, and related research may be expected to help accelerate the development of new cancer therapies. Published in the international magazine Cancer Immunology Research.
Researchers say the new approach may help clinicians choose the best treatment for their patients and help predict which types of tumors are more likely to respond to specific therapies. It also helps in the use of targeted immunotherapy, which is the use of immunotherapy. The patient's own defenses attack cancer. In recent years, immunotherapy has shown great potential in treating a variety of cancers, but how to effectively identify which patients can produce the best response is a huge challenge for clinicians.
The new method developed by the researchers is based on the analysis of genes that can easily find the range of immune cells in a tumor that, when activated by a particular drug, may help detect and kill cancer cells. Traditional therapies such as radiotherapy do not effectively distinguish between different cell types, cancerous cells and healthy cells. These therapies use a one-size-fits-all strategy to attack all cells, often with some side effects.
In this study, researchers analyzed the genes of thousands of tumor samples in medical databases to identify specific genes associated with immune cells. Based on a specific genetic code, researchers can quickly detect the presence of immune cells from tumors. Even when harmful cancer cells are mixed with normal cells, they can effectively detect immune cells. Finally, the researchers said that the results of this study may help scientists to effectively clarify how certain types of immune cells affect cancer growth, and in the future may help clinicians effectively determine which type of cancer patients will best respond to immunotherapy.
Original source: Ajit J. Nirmal, Tim Regan, Barbara B. Shih, et al. Immune Cell Gene Signatures for Profiling the Microenvironment of Solid Tumors. Cancer Immunology Research (2018). DOI: 10.1158/2326-6066.CIR-18- 0342