The study found evidence of beta-amyloid pathology
The study found evidence of beta-amyloid pathology December 28, 2018 Source: Chinese Journal of Science Recently, a paper published online by Nature reported that some batches of cadaveric human growth hormone (c-hGH) samples were contaminated with beta amyloid. Later, these samples were able to propagate beta amyloid pathology in mice. Although these new findings fail to demonstrate the direct spread of Alzheimer's disease, they provide experimental evidence that patients receiving c-hGH are able to transmit beta amyloid pathology. A paper published in Nature in 2015 reported that eight patients had been treated with prion-contaminated c-hGH and later died of Creutzfeldt-Jakob disease (CJD), four of whom had brains Beta amyloid pathology. Amyloid beta pathology is a hallmark of cerebral amyloid angiopathy (CAA) and Alzheimer's disease. Several patients showed pathological features similar to CAA, but none of them completely met the neuropathological criteria for Alzheimer's disease. Although there have been records of CJD interpersonal transmission (iagnostic transmission) in the past due to certain medical means, this study suggests that patients may develop beta amyloid pathology due to c-hGH therapy. John Collinge and colleagues at the Institute of Prion Diseases at the University College London, UK, based on this study, obtained partial c-hGH samples that patients had been exposed to. They used biochemical methods to analyze the presence of amyloid beta and tau, and found that several samples were positive. Later, the researchers studied whether the beta amyloid in the sample might have the potential to propagate beta amyloid pathology in living organisms. The study used genetically engineered mice that expressed the mutant humanized amyloid precursor protein (APP) gene and were injected with c-hGH samples. After 240 days of injection, mice injected with the original c-hGH sample produced beta amyloid deposition and CAA, but this was almost completely absent in the various control mice. The researchers point out that this provides experimental evidence to support the hypothesis that beta amyloid pathology can be transmitted interpersonally in an iatrogenic manner. But the researchers stressed that the study does not mean that Alzheimer's disease is an infectious disease or can be transmitted through blood transfusions, but they believe that assessing the risk of iatrogenic transmission of amyloid pathology is important. One Button Flash Test Splicing Instrument Introduction
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