China's first imported Rift Valley fever virus genome-wide sequence determination completed

China's first imported Rift Valley fever virus genome-wide sequence determination completed

July 26, 2016 Source: shengwugu

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The General Administration of Quality Supervision, Inspection and Quarantine (AQSIQ) was informed that in the early morning of July 24, the Bureau and the Institute of Microbiology and Epidemiology of the Academy of Military Medical Sciences jointly tackled the virus and obtained the genome-wide sequence of the first case of imported Rift Valley fever in China.

"Sequencing results confirmed that the imported case was caused by the infection of Rift Valley fever virus in Africa." Tong Yugang, a researcher at the Institute of Microbiology and Epidemiology, Academy of Military Medical Sciences, told the Science and Technology Daily that the total length of the virus genome was 11980 nucleotides. It is divided into three segments: L, M and S. The lengths are 6404 nucleotides, 3885 nucleotides and 1691 nucleotides, respectively. The highest homology with the South African isolate Kakamas in 2009 is 98%. .

The National Health and Family Planning Commission informed that Tang, who worked in Angola, had fever and headache in Angola on the evening of July 14 (Beijing time), as well as general joint pain and muscle pain. On the evening of July 21, the patient arrived in Beijing and was seriously ill at the time of entry. On the morning of the 23rd, the Beijing Municipal Center for Disease Control and Prevention had positive results for the detection of R&D nucleic acid in patient specimens. On the afternoon of the 23rd, the results of the nucleic acid review of the China CDC were positive. On the evening of the 23rd, the National Health and Family Planning Commission formed an expert group to confirm the case as the first case of imported Rift Valley fever in China based on the epidemiological history, clinical manifestations and laboratory test results. At present, the patient is in critical condition and is actively being treated. Experts believe that the spread of the epidemic is less risky.

Tong Yugang introduced that the successful analysis of the whole gene sequence of Rift Valley fever virus provides important evidence for virus traceability and can be used to guide the research and development of Rift Valley fever virus diagnostic reagents, vaccines and drugs. It is reported that this is the first time in the world to obtain the whole genome sequence of Rift Valley fever virus from Angola, which makes China take the lead in Rift Valley fever virus research and epidemic prevention and control, as well as more accurately diagnose Rift Valley fever and understand Rift Valley fever virus. The variation laid the foundation.

Rift Valley fever is an acute infectious disease caused by Rift Valley fever virus. The incubation period is 2-6 days. The epidemic source is mainly distributed in eastern and southern Africa. The main source of infection of Rift Valley fever is sheep, cattle, camels and other animals in the source of the disease. People are mainly caused by direct contact with tissues, blood, secretions, excretions or consumption of uncooked meat, milk, etc. Spread by mosquito bites, there have been no reports of human-to-human transmission. Most people infected with Rift Valley fever virus are latent infections. A few patients have symptoms such as fever, hepatitis, retinitis, hemorrhagic syndrome and meningoencephalitis after infection. Some cases may show multiple system damage.

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