Release date: 2018-04-04

Scientists have discovered a "two-pronged approach" to treat non-small cell lung cancer by "starving" it by not allowing cancer cells to eat or let it break down its own protein.

Non-small cell lung cancer is the most common type of lung cancer, and many non-small cell lung cancers are caused by mutations in the KRAS gene. Institutional researchers such as Boston Children's Hospital in the United States published a paper in the Proceedings of the National Academy of Sciences on the 2nd that insulin and insulin-like growth factor-1 are important factors affecting cell growth. They used KRAS mutant mice as research objects and tried to Insulin and insulin-like growth factor-1 signaling were completely blocked, and as a result, tumor growth in the lungs of mice was significantly inhibited.

However, blocking insulin and insulin-like growth factor-1 signaling does not completely inhibit tumor growth. The researchers said that growth factors such as insulin-like growth factor-1 will tell the cells that there are nutrients around them; after suppressing the related signal transduction, the tumor cells will "starve" because they cannot take the necessary amino acids. However, tumor cells do not sit still, but decompose their own proteins to produce amino acids.

The researchers conducted animal experiments and inhibited insulin and insulin-like growth factor-1 signaling as well as protein breakdown, and found that tumor growth was almost completely inhibited.

Source: Xinhuanet

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