The mystery of metastasis of breast cancer cells is determined by self-phagocytic mechanism to ensure long-term survival.
The mystery of metastasis of breast cancer cells is determined by self-phagocytic mechanism to ensure long-term survival. May 24, 2018 Source: Science and Technology Daily According to a cancer research published by the British journal Nature Communications on the 22nd, a team of scientists at the National Cancer Institute of the United States found through a 3D model that breast cancer cells migrate to other organs and remain dormant, through autophagy. Make sure you can survive for a long time. Breast cancer has become a major public health problem in the current society. In fact, the breast is not an important organ to maintain human life, and breast cancer in situ is not fatal. However, when breast cancer cells lose the characteristics of normal cells, the connections between the cells become loose and easily fall off, and free cancer cells can spread throughout the body with blood or lymph, forming a metastasis. One of the most common causes of breast cancer death is the recurrence of tumors after initial diagnosis and treatment, which is caused by the metastasis of dormant tumor cells. However, the cause of long-term survival of dormant breast cancer cells is still little known to date. Autophagy is an important mechanism of cell self-repair: the decomposition of part of the cell contents that are no longer needed, and recycling. Many diseases in the human body are related to the regulation of autophagy. In recent years, studies have shown that autophagy may play an extremely important role in the pathogenesis of breast cancer. This time, analysis by Kent Hunter, a scientist at the National Cancer Institute, and colleagues showed that metastatic breast cancer cells remain dormant by autophagy and survive in other organs. Using 3D cell and mouse models, the team found that blocking the autophagy of these dormant breast cancer cells through genetic manipulation and pharmacological inhibitors can impede their survival and inhibit tumor growth in other organs far from the breast. The team also found that inhibition of autophagy can reduce the viability of tumor cells because of the accumulation of damaged mitochondria and oxidative stress, leading to cell death. Scientists believe that based on this research, targeting autophagy targeted interventions, or can prevent breast cancer recurrence, thereby reducing the harm of women's physical and mental health "killer". (Reporter Zhang Mengran) YT-H706 YT-H706 Shenzhen Sunshine Technology Co.,Ltd , https://www.yatwin.com