Scientists have found that exhaustion of immune T cells is associated with DNA methylation

In the long-term confrontation with viruses or cancer cells, the body's immune cells will get tired, and some of them completely lose their combat power and are difficult to recover. American scientists have recently discovered the reasons:

Complete depletion of immune T cells is associated with DNA methylation processes.

T cells are the main force of the immune system and viruses and cancer cells. Their loss of function is called T cell depletion, which will reduce the body's immunity and gain pathogens. Some immunotherapies can encourage T cells to re-enter the battle, but do not work on completely depleted T cells, leading to immunotherapy that is ineffective for many patients, or relapses after the disease has subsided.

科学家发现免疫T细胞彻底耗竭与DNA甲基化有关

Scientists at the St. Jude Children's Research Hospital in the United States reported in a new issue of Cell, Inc. that they found that the complete depletion of immune T cells is linked to DNA methylation, a ready-made cancer chemotherapy that allows T cells to rekindle. stand up.

DNA methylation refers to the selective addition of methyl to cytosine, one of the constituent units of DNA, which changes the shape of the DNA strand, causing some proteins to fail to correctly recognize DNA, and may also not "open" or "normally" Turn off the function of some genes.

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