Pharmaceutical Grade Ampicloxaxillin for Wide Antibiotic Spectrum 500mg
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[drug name]
Pharmaceutical Grade Ampicloxaxillin for Injection
[character]
This product is white powder or crystalline powder.
[pharmacological toxicology]
This product is a semisynthetic penicillins, has the characteristics of acid-resistant, resistant to penicillin enzyme, the gram positive coccus and neisseria bacteria have antibacterial activity, is against staphylococcus (including staphylococcus aureus and coagulase negative staphylococcus) enzyme production strains of the antimicrobial activity of the benzene azole west er, but sensitive to penicillin penicillin staphylococcus and streptococcus kinds of antibacterial effect is weak, of methicillin resistant staphylococcus aureus is invalid.
[pharmacokinetics]
Intramuscular injection of 0.5g of chlorazole, the concentration of blood drug peak (Cmax) reached 0.5 hours, which was 15mg/L.
Three hours of intravenous drip of chloroazole, 0.75 g, and the blood drug concentration were 15mg/L and 0.6mg/L respectively.
The serum protein binding rate of this product is 94%, which can penetrate into bone tissue, pus and joint cavity effusion in patients with acute osteomyelitis, and high concentration in pleural effusion.
The fetus can also be entered through the placenta, but it is difficult to penetrate the normal blood-cerebrospinal barrier.
Chlorine azole Westwood blood elimination half-life (t1/2 b) 0.5 ~ 1.1 hours, mainly through the glomerular filtration and renal tubular secretion, since the eduction in urine, after intravenous drip annotated product, about 62% since the urine, about 6% since the bile discharge, small amounts in the liver metabolism.
[indication]
This product applies only to staphylococcus aureus infection, including septicemia, endocarditis, pneumonia and skin, soft tissue infection, etc.
It can also be used for the mixed infection of the suppurative streptococcus or pneumococcus and the staphylococcus aureus.
[usage]
 Patients with mild and moderate renal impairment should not need to adjust the dosage, and patients with severe renal impairment should avoid using large doses to prevent the toxic reaction of the central nervous system.
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adult
children
Newborns
More than 2kg of weight
Intramuscular injection
2g, 4 times per day
25 ~ 50mg/kg per day, 4 times.
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Intravenous drip injection
4 ~ 6g, 2 ~ 4 times
weigh 50 to 10mg/kg a day, two to four times
weighing less than 2kg, weight to 25mg/kg every 12 hours from 1 to 14 days of age, and 25mg/kg per 8 hours from 15 to 30 days of age
25mg/kg per 8 hours per 8 hours of daily age from 1 ~ 14 days, and 25mg/kg per 6 hours of daily age 15 ~ 30 days
[adverse reactions]
1.Anaphylaxis: a variety of skin rash such as urticaria can be seen, leukocyte reduction, interstitial nephritis, asthma attacks and other symptoms can also occur, such as anaphylactic shock occasionally;In the event of anaphylactic shock, it is necessary to rescue in situ, maintain the airway, absorb oxygen and give the treatment such as epinephrine and glucocorticoid.
2.Intravenous injection of this product can produce nausea, vomiting and serum aminotransferase.Â
3.A large dose of injection can cause a toxic reaction of central nervous system such as tics.
4.There are reports of hematuria, proteinuria and uremia after the use of large doses of this product.
5.Individual cases of granulocytic deficiency or stasis jaundice.
[contraindications]
Patients with penicillin or skin test positive for penicillin are prohibited.
[Notes]
1.Drug allergy history and penicillin skin test are required before applying this product.
2.Allergic to other penicillin drugs or penicillium for an allergic to penicillin.
3.Patients with allergic diseases such as asthma, eczema, hay fever and urticaria should be used with caution.
4.This product reduces the combination of bilirubin and serum protein, and neonates especially those with jaundice should use this product with caution.
[medication for pregnant and lactating women]
There is no adequate study of the impact of this product on pregnant women, so pregnant women should only use this product if necessary.
A small amount of this product is secreted in milk, so that lactation is applied to lactation.
Children's medication
Neonates especially preterm infants should be used with caution.
[drug interactions]
1.This product is incompatible with aminoglycoside, norepinephrine, hydroxylamine, phenobarbital, vitamin B, vitamin C and other drugs.
2.Propion can reduce the renal tubule secretion of chlorazole and prolong the serum half-life of the product.Â
3.The combination of aspirin and sulfa drugs to suppress the serum protein and improve the concentration of free blood.Â
[specifications]
500mg
[storage]
Sealed in a dry place.
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