Release date: 2018-02-07

Treatment of leukemia, hematopoietic stem cell transplantation (commonly known as bone marrow transplantation) is one of the effective cures, but according to traditional theory, "human leukocyte antigens are always the preferred donor", bone marrow transplantation requires donor and recipient human leukocyte antigens consistent Otherwise, it is very prone to serious rejection, but finding a transplant matching is like finding a needle in a haystack. The lack of bone marrow donor source has become a worldwide problem.

Huang Xiaojun proposed that "the bone marrow transplant does not need to be fully matched" to solve the problem of donor source. The haplotype is the best solution. Haplotype transplantation is the transplantation between parents and children, and cousin, only requires the matching of human leukocyte antigens. This technology will be a patient who needs hematopoietic stem cell transplantation but cannot find a homogeneous fit. Provide more opportunities for treatment. This technical solution was called "Beijing Program" by international counterparts.

Huang Xiaojun led the team to conduct research in the field of semi-matched transplantation from more than a decade ago. T cells in bone marrow stem cells are obstacles that are difficult to cross. T cells are highly aggressive, attacking normal cells in patients, leading to anti-host disease, killing tumor cells, and becoming the fulcrum for patients to re-establish immunity. What can "stay" T cells is a drug called granulocyte colony-stimulating factor. It can drive the hematopoietic stem cells in the bone marrow to the peripheral blood, make the T cells become "sputum", and add a drug that temporarily suppresses the T cell function, anti-thymocyte drugs, forming the prototype of the "Beijing program." In 2014, with this program, Huang Xiaojun clinically achieved the anti-leukemia effect and the graft-versus-host disease separation, improved the safety and effectiveness of hematopoietic stem cell transplantation, and first boarded the national science and technology award podium.

Nowadays, the overall survival rate of patients with acute leukemia and severe aplastic anemia in the “Beijing Program” is 75%-89%, which is consistent with the effect of sibling transplantation, so that haplotype donors can replace the full contracted donors. "To achieve a hematopoietic stem cell transplant donor." At present, the Department of Hematology of Peking University People's Hospital, led by Huang Xiaojun, has become the world's largest haploid transplant center and the transplant center with the highest patient survival rate. The “Beijing Program” was promoted to 92 transplant centers nationwide and more than 10 overseas centers such as France and Italy.

However, the widespread use of haplotype transplantation has brought new questions: Who is the best donor of hematopoietic stem cell transplants? Can haplotype transplantation be the first choice and not just a backup supplement for human leukocyte antigen sibling transplantation?

Huang Xiaojun's research group conducted a comparative study. One group was 514 cases of human leukocyte antigen sibling transplantation in Peking University People's Hospital, and the other was 685 cases of "Beijing program" haplotype transplantation. Two types of 3-year disease-free survival rate. 74% and 75%, respectively; donors are preferred for young, male, and ABO blood group.

"Clinical studies have found that haplotype transplantation is consistent with classic sibling transplantation. The transplantation model is not the main factor affecting the survival of patients. For patients, the age of donors is really coming." Huang Xiaojun said, the latest research It is expected that bone marrow transplantation will enter a "precise" era based on the patient's specific condition, stratification or even individualized donor selection.

"My immediate goal is to do a better transplant, but the real dream is to eliminate bone marrow transplants," Huang Xiaojun said.

Source: People's Daily

Female Health Care Material

Grape seed extract;Astaxanthin;Anthocyanins(Anthocyanins are a powerful anti oxidant, which protects the body from damage caused by a harmful substance called free radicals. Anthocyanins also enhance the elasticity of blood vessels, improve the circulatory system and smoothness of the skin, inhibit inflammation and allergies, and improve the flexibility of joints. );Vitamin C powder

Anthocyanin;Grape seed extract;Astaxanthin;Polyphenol

Shaanxi Zhongyi Kangjian Biotechnology Co.,Ltd , https://www.zhongyibiotech.com