Breast cancer is the second most common tumor in the world, and its incidence rate is the highest in women's tumors. Until 2012, there were 1.67 million new cases of women worldwide, accounting for 25% of all tumors. HER-2 receptor-positive breast cancer accounts for 25-30% of breast tumors with poor prognosis. Therefore, the active development of HER-2 receptor targeted therapy HER-2 receptor targeted therapy is crucial for the treatment of HER-2 breast cancer. At present, the conventional treatment of breast cancer shows obvious toxic and side effects, which seriously affects the quality of life of patients. The chemical substances contained in dietary plants are widely available in the diet, are easy to obtain, have low toxic and side effects, and can play an active role in the prevention and adjuvant treatment of breast cancer.

In recent years, the anticancer effect of flavonoid anthocyanins has attracted attention, and it has been found to exert anti-proliferative and metastatic effects in addition to antioxidant effects. However, there is still an unclear part of the mechanism of anthocyanin against HER-2 breast cancer. As one of the six main monomers of anthocyanins, delphinidin is highly abundant in anthocyanins and has strong activity. It is considered that the anticancer effect is superior to other anthocyanin monomers and is the subject of this study.

Autophagy is a purifying and retaining process that exhibits a double-edged sword effect in anti-cancer effects. When cells are in a malignant microenvironment such as starvation or metabolic stress, they can mediate intracellular longevity protein transformation and eliminate damage or Excess organelles maintain cell metabolism and play a role in protecting cancer cells. In recent years, studies have been more realistic, and the protective effect of inhibiting autophagy is crucial for the anti-cancer effect of sensitizing chemotherapy. Therefore, this article will investigate whether delphinidin can induce the proliferation of HER-2 breast cancer cells MDA-MB-453. Protective autophagy and inhibition of autophagy can enhance the anti-HER-2 breast cancer effect of delphinidin.

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