Naturally fluorescent anthracycline antibiotic, anticancer drug. Doxorubicin is a substrate of MRP1 which was first cloned from a DOX-resistant lung cancer cell line. Fluorescent property has been exploited for the measurement of drug efflux pump activities as well as resolving the important question of intracellular localization of various multidrug resistance proteins and the role of subcellular organelles (Golgi and lysosome) in the sequestration of drugs and its implication in drug resistant phenotypes.
It is a drug used in cancer chemotherapy. It is an anthracycline antibiotic, closely related to the natural product daunomycin, and like all anthracyclines, it works by intercalating DNA, with the most serious adverse effect being life-threatening heart damage. It is commonly used in the treatment of a wide range of cancers, including hematological malignancies, many types of carcinoma, and soft tissue sarcomas.
Application:  1 Hodgkin's disease and lymphosarcoma, reticulum cell sarcoma. 2 Undifferentiated small cell and non-small cell lung cancer, breast cancer. 3 Acute lymphoblastic and myeloid leukemia. 4 Osteosarcoma and soft tissue sarcoma. 5 Ovarian cancer, testicular cancer, bladder cancer, . Wilms cancer, prostate cancer, thyroid cancer, neuroblastoma cancer, esophageal cancer, stomach cancer, liver cancer, cervical cancer and head and neck cancer. Multiple myeloma, pancreatic cancer, endometrial cancer and brain tumors can also be applied.Â
Uses:
1.Used as an antineoplastic
2.Strong fluorescent dye intercalating into DNA. Antitumour antibiotic. Effect of adriamycin on heart mitochondrial DNA. Inhibitor of reverse transcriptase and RNA polymerase; immunosuppressive agent.
3.Doxorubicin hydrochloride (adriamycin hydrochloride) is an antitumour agent that has been formulated as a salt to achieve higher water solubility. While the salt shares the same pharmacological properties as doxorubicin free base, its greater water solubility may offer advantages in some in vitro applications.Â
Physicochemical properties and chromatographic behaviour will depend on whether the pH is buffered. In non-pH controlled systems the free base and salt may behave differently.
4.Doxorubicin is an anthracycline antitumor antibiotic that inhibits DNA topoisomerase II by inducing double-stranded DNA breaks. By intercalating within DNA, doxorubicin inhibits nucleic acid synthesis and induces apoptosis by inducing the accumulation of the p53 tumor suppressor protein.
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The quality control process:
1)Purchasing Thorough market research, understand the price of raw materials and performance.To the procurement source to understand fully, and fully guarantee the quality of the procurement of raw materials. 2) Inspection Four steps: sampling, sample pretreatment, measuring and data processing. 3) Producing a)Each operator must do self-inspection of products and make the corresponding inspection records. b)Full-time inspectors through check the operator self-inspection, and review and sign in the corresponding record. Full-time inspection is responsible for inspection of finished product, and make the finished product incoming inspection records. 4) Before selling Test result can be provided before selling. Third-party detection institution is allowed if you are not satisfied with test results.
Our Advantages:
1. Rich experience: Our company is a professional production leading factory in China in pharmaceutical area of many years.Â
2. Top quality: High quality guaranteed, once any problem is found, the package would be reshipped for you .
3. Security Shipping: Shipping by express (FedEx,UPS,DHL,EMS), by air. The most professional forwarder would be recommanded for you.
4. Fast delivery: We have stock, so we can delivery quickly once payment is received.
5. Quality service: We will give you warm after-sale service,if any question we will reply you within 24 hours.
6. Competitive prices: A discount would be given when you make a large order.
Order Process and Tips: Â
Make an order
Please make clear what product and what quantity you need
Quote
Prices and Specifications details would be offered for you to consider and confirm
Payment ways
Bank Transfer, Western Union, Money Gram and Bitcoin
Delivery ways
All Express Modes(EMS, DHL, TNT, FedEx, UPS, etc.)
Shipping address
Provide your Valid and Correct destination address info(if possible with post code, phone number).
Packing
Select best ways according to quantity and safety degree(Super discreet, professional and experienced)
Lead time
Within 8 hours upon receipt of payment
Package picture
Photos of package would be offered to tell apart the items
Tracking number
Offered once it is released
Shipping time
3-7 working days (Door-to-Door)
After-sale service
24/7 Online for any problems
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99% Factory Direct Antineoplastic Raw Powder Doxorubicin Hydrochloride CAS 25316-40-9
Naturally fluorescent anthracycline antibiotic, anticancer drug. Doxorubicin is a substrate of MRP1 which was first cloned from a DOX-resistant lung cancer cell line. Fluorescent property has been exploited for the measurement of drug efflux pump activities as well as resolving the important question of intracellular localization of various multidrug resistance proteins and the role of subcellular organelles (Golgi and lysosome) in the sequestration of drugs and its implication in drug resistant phenotypes.
It is a drug used in cancer chemotherapy. It is an anthracycline antibiotic, closely related to the natural product daunomycin, and like all anthracyclines, it works by intercalating DNA, with the most serious adverse effect being life-threatening heart damage. It is commonly used in the treatment of a wide range of cancers, including hematological malignancies, many types of carcinoma, and soft tissue sarcomas.
Application:  1 Hodgkin's disease and lymphosarcoma, reticulum cell sarcoma. 2 Undifferentiated small cell and non-small cell lung cancer, breast cancer. 3 Acute lymphoblastic and myeloid leukemia. 4 Osteosarcoma and soft tissue sarcoma. 5 Ovarian cancer, testicular cancer, bladder cancer, . Wilms cancer, prostate cancer, thyroid cancer, neuroblastoma cancer, esophageal cancer, stomach cancer, liver cancer, cervical cancer and head and neck cancer. Multiple myeloma, pancreatic cancer, endometrial cancer and brain tumors can also be applied.Â
Uses:
1.Used as an antineoplastic
2.Strong fluorescent dye intercalating into DNA. Antitumour antibiotic. Effect of adriamycin on heart mitochondrial DNA. Inhibitor of reverse transcriptase and RNA polymerase; immunosuppressive agent.
3.Doxorubicin hydrochloride (adriamycin hydrochloride) is an antitumour agent that has been formulated as a salt to achieve higher water solubility. While the salt shares the same pharmacological properties as doxorubicin free base, its greater water solubility may offer advantages in some in vitro applications.Â
Physicochemical properties and chromatographic behaviour will depend on whether the pH is buffered. In non-pH controlled systems the free base and salt may behave differently.
4.Doxorubicin is an anthracycline antitumor antibiotic that inhibits DNA topoisomerase II by inducing double-stranded DNA breaks. By intercalating within DNA, doxorubicin inhibits nucleic acid synthesis and induces apoptosis by inducing the accumulation of the p53 tumor suppressor protein.
Â
The quality control process:
1)Purchasing Thorough market research, understand the price of raw materials and performance.To the procurement source to understand fully, and fully guarantee the quality of the procurement of raw materials. 2) Inspection Four steps: sampling, sample pretreatment, measuring and data processing. 3) Producing a)Each operator must do self-inspection of products and make the corresponding inspection records. b)Full-time inspectors through check the operator self-inspection, and review and sign in the corresponding record. Full-time inspection is responsible for inspection of finished product, and make the finished product incoming inspection records. 4) Before selling Test result can be provided before selling. Third-party detection institution is allowed if you are not satisfied with test results.
Our Advantages:
1. Rich experience: Our company is a professional production leading factory in China in pharmaceutical area of many years.Â
2. Top quality: High quality guaranteed, once any problem is found, the package would be reshipped for you .
3. Security Shipping: Shipping by express (FedEx,UPS,DHL,EMS), by air. The most professional forwarder would be recommanded for you.
4. Fast delivery: We have stock, so we can delivery quickly once payment is received.
5. Quality service: We will give you warm after-sale service,if any question we will reply you within 24 hours.
6. Competitive prices: A discount would be given when you make a large order.
Order Process and Tips: Â
Make an order
Please make clear what product and what quantity you need
Quote
Prices and Specifications details would be offered for you to consider and confirm
Payment ways
Bank Transfer, Western Union, Money Gram and Bitcoin
Delivery ways
All Express Modes(EMS, DHL, TNT, FedEx, UPS, etc.)
Shipping address
Provide your Valid and Correct destination address info(if possible with post code, phone number).
Packing
Select best ways according to quantity and safety degree(Super discreet, professional and experienced)
Lead time
Within 8 hours upon receipt of payment
Package picture
Photos of package would be offered to tell apart the items
