Structure design of non-blocking pump impeller
The main structural forms currently used as non-blocking pump impellers are: 1. Open or semi-open impeller; 2. Swirling impeller; 3. Single (double) flow path impeller; 4. Screw centrifugal impeller. These types of non-blocking impellers have their own characteristics, and the applicable occasions are also different, as follows: Open or semi-open impellers - if the wear gap is increased, the pump performance is degraded, and the non-blocking performance is poor, and large particles and long fiber materials cannot be transported; Swirling impeller - good non-blocking performance, good wear resistance, suitable for conveying large particulate matter, but poor non-destructive, large damage to the transport material, can transport liquid containing gas, not suitable for transporting liquid containing long fiber material; Single-flow impeller - good non-destructive to the conveying material, good non-blocking performance, suitable for conveying large particles and long fiber materials, and good wear resistance, but high balance requirements and poor running balance; Double-flow impeller - the passing capacity is slightly worse than the single-flow passage, but because of the symmetrical flow passage, the balance performance is good, the operation is stable, and it is suitable for high-lift, high-flow pumps; Spiral centrifugal impeller - good non-blocking, suitable for liquids containing particles and fibrous substances, low destructive to the transport material, that is, good nondestructive, but high requirements for balance. LCZ696 (Valsartan/sacubitril) is a combination drug for use in heart failure developed by Novartis. It consists of the angiotensin receptor blocker valsartan and the neprilysin inhibitor sacubitril, in a 1:1 mixture by molecule count. It may be used instead of an ACE inhibitor or an angiotensin receptor blocker in people with heart failure with reduced ejection fraction. The combination is sometimes described as an "angiotensin receptor-neprilysin inhibitor" (ARNi).
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Lcz696 Intermediates,Cas 1426129-50-1,Cas 1012341-50-2,High Purity Lcz696 Intermediate Nanjing Sunshine Biotech Co., Ltd , http://www.sunshine-bio.com
It was approved under the FDA's priority review process on July 7, 2015. It is also approved in Europe.
We produce a series of complete intermediates for LCZ696, intermediate I (CAS No. 1426129-50-1) and intermediate II (CAS No. 1012341-50-2) etc.