Chinese scientists say that skin cells are expected to become retina
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"The pathogenesis and prevention of important neurological blindness in China" is the only project in the ophthalmology field of the "973 Program". It is led by Prof. Ge Jian, Director of the State Key Laboratory of Ophthalmology, Sun Yat-Sen University, bringing together the current ophthalmology. The research field* scientists are conducting joint research.
Ge Jian told reporters that the causes of "neurological blinding eye disease" are various, and retinal nerve cells can not be regenerated after apoptosis. If stem cells are transplanted into the retina, it is expected to regenerate into retinal neurons, or activate residual retinal neurons in patients, providing the possibility for blind patients to see the light again. Ge Jian said happily: "We have clearly observed that mouse adult fibroblasts possess the characteristics of pluripotent stem cells through transgenic technology." By inducing directional differentiation of these adult cell-derived pluripotent cells, it is possible in the future to A variety of retinal neuropathies provide seed cells. In addition, the research team led by Ge Jian injected the monkey's somatic cells into the mouse embryo through microinjection technology to generate "monkey mouse chimeric mice". The researchers detected male constants in these "monkey rats". The rhesus genes are distributed in the cornea, retina, skin, liver, blood, nervous system and other tissues of the monkey. Next, the animal experiment of rhesus monkeys will continue, followed by late clinical validation. If the conditions are ripe, scientists may use this method to create human organs in animals, and many human incurable diseases will be cured.
It is reported that scientists in the United States and Japan are making rapid progress in this field. Ge Jian told reporters comfortably that in the aspect of "the pathogenesis and prevention and treatment of neurological blindness caused by eye diseases", China has been synchronizing with the world and has made important progress in stages, and innovatively proposed in screening, diagnosis and prevention. "Stage target intervention theory", "drug sustained release system", stem cell replacement therapy and other methods. In the next 5-10 years, these research results are expected to be applied to the clinic to improve the diagnosis and treatment of neurological blindness and reduce the blindness rate.