According to a report published online by the British journal Nature Microbiology on the 11th, American scientists discovered a new class of antibiotics by extracting soil bacterial DNA and sequencing it. The new antibiotic, named Malacidins, kills many multidrug-resistant and disease-causing bacteria, even methicillin-resistant Staphylococcus aureus (MRSA), which causes skin infection in rats.

Antibiotics are essentially a class of secondary metabolites produced by microorganisms (including bacteria, fungi, actinomycetes) or higher plants and animals during their life. They have anti-pathogenic or other activities that interfere with the developmental functions of other cells. . At present, the scientific community believes that new antibiotics are needed to curb the increasing trend of drug-resistant infections. But in the past 30 years, only a very small number of new antibiotics have been developed, and new antibiotics are urgently needed to fight multidrug-resistant pathogens.

Given that most of the finally licensed antibiotics were originally extracted from microbes, the focus of scientists at this stage is to find new drugs from different environmental samples. This time, Sean Brady, a researcher at Rockefeller University in the United States, and colleagues collated the bacterial DNA extracted from more than 1,000 soil samples from all over the United States and finally discovered a group of genes that produced the new antibiotic Malacidins. Malacidins fight bacteria differently than other drugs, which attack critical parts of the bacterial cell wall. In the laboratory, microorganisms are not resistant to this mechanism.

In this study, the team also adopted a high-throughput, sequencing-based screening method that eliminated the steps of cultivating microorganisms. Previously, most bacterial species could not be cultivated in the laboratory, so the new method can be used to quickly find candidate drugs from a variety of environmental samples.

Editor-in-chief

Bacteria have become more and more powerful in the game of antibiotics. They will camouflage, will wear armor, and will mutate. The height of the magic is one foot high, and the antibiotics have to be upgraded. Otherwise, the gang of bacteria will not be able to be built. American scientists extracted DNA from soil bacteria to find new antibiotics, temporarily giving the antibiotic family a "king". But no one can relax this, because there are super bacteria in the super antibiotics, this "cat and mouse game" seems to have no end. If scientists from other countries in the world also extract bacterial DNA from their own soil, will they find other new antibiotics with local characteristics? (Technology Daily)

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