Release date: 2017-09-06

The reporter learned from the People's Hospital of Wuhan University that the international authoritative medical journal "Circulation" recently published the latest research results of the research team of Professor Li Hongliang of the Department of Cardiology of the hospital on the mechanism of angiogenesis and endometrial formation, revealing for the first time that interferon regulatory factor IRF4 inhibits arteries. The mechanism of neointimal formation and is expected to provide a new breakthrough in preventing restenosis after arterial stenting.

According to the data of China's coronary heart disease intervention published by the 20th National Interventional Cardiology Forum in 2016, there were 666,495 cases of interventional treatment in mainland China in 2016, and the average number of implanted patients in coronary heart disease was 1.5. However, studies have shown that even with drug-eluting stents that are effective in reducing the risk of coronary restenosis, approximately 2% to 5% of patients may have in-stent restenosis within 8-12 months after surgery. The main cause of stent restenosis is the neointimal hyperplasia of the coronary vessels in patients. For a long time, it is still unclear how to study the formation mechanism of angiogenic intima. How to avoid stent restenosis has been plaguing clinicians.

Professor Li Hongliang's team showed that the expression of interferon regulatory factor 4 was down-regulated in human and mouse restenosis vessels; if the interferon regulatory factor 4 gene was knocked out in mice and rats, the neovascular intima was evident. increase. The study also found that interferon regulatory factor 4 is mainly expressed in smooth muscle cells in arteries with restenosis; whereas in arterial impaired, smooth muscle cell-specific interferon regulatory factor 4 knockout mice are smaller than normal The mouse forms a thicker neointimal. At the same time, the proliferation and migration ability of vascular smooth muscle cells was significantly increased. In mice with vascular smooth muscle cells overexpressing the interferon regulatory factor 4 gene, the opposite result was observed.

This significant original research result of Professor Li Hongliang's team provides a new theoretical basis for further elucidation of the formation mechanism of coronary angiogenic neointimal after stenting.

Source: Technology Daily

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